CCOG for APR 224L archive revision 202604

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Effective Term:
Fall 2026

Course Number:
APR 224L
Course Title:
Clinical Chemistry I
Credit Hours:
3
Lecture Hours:
30
Lecture/Lab Hours:
0
Lab Hours:
0

Course Description

Presents basic theory of commonly ordered tests in the clinical chemistry laboratory, including: the physiological basis for the test, specimen type, test principles, expected values, sources of error, limitations of the test, and disease correlation. Covers general laboratory principles, methodologies, theories, instrumentation, and concepts associated with testing procedures used in the clinical chemistry laboratory. Introduces important characteristics and clinical significance of carbohydrates, proteins, enzymology, liver function, endocrinology, and cardiac markers. Lab skills will be acquired through on-the-job training.

Intended Outcomes for the course

Upon successful completion of the course, students should be able to:

  1. Perform analytical testing of basic chemistry analytes: glucose, enzymes, proteins, and hormones.

  2. Interpret laboratory results and correlate data with disease states.

Course Activities and Design

This online course is delivered through lecture/discussion, audio-visual presentations, handouts, web-based instructional media, and other educationally sound practices. Hands-on laboratory content will be learned through on-the-job training, with classroom instruction focusing on the theoretical background necessary to perform laboratory tasks. There is no laboratory component in this course.

Outcome Assessment Strategies

Assessment methods may include written examinations, homework assignments, quizzes, and discussion activities. Evaluation will focus on students’ understanding of theoretical knowledge, problem-solving skills, communication, and comprehension of clinical laboratory protocols, safety regulations, and quality assurance measures. Practical lab skills will be assessed during on-the-job training, rather than in the classroom.

Course Content (Themes, Concepts, Issues and Skills)

  1.  

Course Themes:

  1. Carbohydrates

  2. Glucose metabolism and regulation

  3. Diseases associated with glucose metabolism

  4. Metabolic relationships

  5. Laboratory procedures for glucose analysis

  6. Enzymology

  7. Enzyme structure and function

  8. Enzymes and their associated tissues

  9. Diseases and conditions detected and monitored by circulating enzymes

  10. Laboratory methodologies for enzyme measurement

  11. Enzyme role in laboratory analysis of other analytes

  12. Liver Function

  13. Etiology and pathophysiology of hepatitis and other liver diseases

  14. Liver function panel

  15. Bilirubin, pathophysiology and laboratory testing

  16. Endocrinology

  17. Hormones, pathophysiology and laboratory testing of the thyroid, adrenal and reproductive glands

  18. Proteins

  19. Protein structure and function

  20. Laboratory methods for protein measurement and differentiation

  21. Correlation of various diseases and conditions with protein values

  22. Protein Electrophoresis

  23. Principles and application of serum electrophoresis

  24. Normal and abnormal serum electrophoresis patterns

  25. Cardiac Markers

  26. Etiology and pathophysiology of atherosclerosis

  27. Laboratory tests associated with myocardial infarction diagnosis and risk assessment of cardiac vascular disease

Course Skills:

Cognitive Skills:

  • Explain chemistry theory supporting test principles

  • Integrate knowledge and make informed judgments about clinical chemistry test results 

  • Predict expected results

  • Draw appropriate conclusions based on test results


Performance and Professional Skills:

  • Demonstrate initiative, adaptability, and professionalism through classroom participation and discussions.

  • Engage with course materials independently, showing motivation and commitment to learning.

Safety Awareness Skills:

  • Recognize laboratory safety equipment and proper usage.

  • Understand the importance of safety measures in preventing accidents and exposure to pathogens.