The Neighborhood House Oregon Head Start Pre-kindergarten Program serves children from birth to age 5 in West Multnomah County. The program serves 120 children in a combination of four preschool classrooms, a home-based program, and Early OPK. The Neighborhood House OPK program is a State of Oregon funded program based on the Federal Head Start program. This child and family development program serves primarily low income children aged 3-5. At least 10% of enrollment opportunities are made available for children with disabilities, regardless of income.

The preschool classrooms are open five days a week, with classes scheduled from 8:15 a.m. to 12:15 p.m., and 9:30 a.m. to 1:30 p.m. Parent/Child socialization groups are held for two hours, twice a month, for the home-based OPK enrollment; and once a week for the Early OPK enrollment. Volunteers are welcomed as classroom aides, to assist with health and developmental screenings, for building and yard maintenance, and as kitchen aides. Volunteer opportunities are available at three different locations.