## Course Content and Outcome Guide for BIT 107

- Course Number:
- BIT 107
- Course Title:
- Bioscience Lab Math
- Credit Hours:
- 2
- Lecture Hours:
- 20
- Lecture/Lab Hours:
- 0
- Lab Hours:
- 0
- Special Fee:

#### Course Description

Develops mathematics skill and problem-solving related to work in a bioscience laboratory or biomanufacturing environment. Includes calculations for solution preparation, analysis and manipulation of molecules and cells, analysis and interpretation of data and commonly used statistical methods. Prerequisite: MTH 65 or placement into MTH 95. Recommend: Prior or concurrent college-level course in Chemistry, or BI 112 or 211. Audit available.#### Addendum to Course Description

This course is also recommend for beginning chemistry students to assist them in laboratory calculations.

#### Intended Outcomes for the course

Carry out calculations needed to prepare solutions, make dilutions, interpret protocols and evaluate data in bioscience laboratory or manufacturing environment.

#### Outcome Assessment Strategies

Assessment will include multiple in-class exams in each unit as specified below (Course Content/Skills). The testing and scoring method will reflect consistent competency of computational demands

Additional assessment measures may include, but are not limited to, take-home examinations, graded worksheets/homework, in class participation and attendance.

#### Course Content (Themes, Concepts, Issues and Skills)

COURSE CONTENT:

THEMES, CONCEPTS, ISSUES

- Attention to detail
- Consistency, accountability and integrity
- Calculation for solution and media preparation
- Analysis and manipulation of biological molecules and cells
- Interpretation of data

COMPENTENCIES AND SKILLS:

Unit 1 Manipulation of Scientific numbers and Units

- Manipulate mathematical calculations using the SI (Systeme International)
- Transform numbers into and out of scientific notation
- Carry out conversions between scientific notation and SI with appropriate prefixes
- Recognize the difference between exact and measured numbers
- Identify the correct number of significant figures and apply appropriately
- Follow the rules for rounding used internationally by scientists
- Express the differences between accuracy and precision
- Collect and utilize pertinent information from the Periodic Table of the Elements
- Execute calculations using powers of ten
- Determine the number of moles, molecules and grams in a given amount of a specific chemical solution
- Compute g/mole conversions using dimensional analysis
- Label mathematical calculation s during all stages of solution process with SI units/prefixes

Unit 2: Calculations for solution Preparation Ã different expressions for concentration

- Distinguish between amount and concentration and use these terms appropriately
- Calculate weight to volume concentrations using dimensional analysis and/or proportion
- Define Molarity and its abbreviations, and use appropriately
- Execute calculation to determine the number of moles or grams in solutions of specified volume and Molarity
- Distinguish between the three types of percent concentration, (w/w, w/v, and v/v)
- Define BTV and QS (quantum sufficient) and apply them appropriately
- Interpret and manipulate solution preparations given in parts
- Execute comparisons/solutions using ppm and ppb
- Distinguish between Molarity, molality and normal solutions
- Identify acid and base equivalents for Normal solutions
- Solve for various preparation amounts for Molar and Normal solutions
- Calculate water of hydration intro formula weight
- Define density and apply to solution methods when appropriate

Unit 3: Calculations for Dilutions

- Execute mathematical calculations for dilutions of concentrated solutes
- Grasp the divers terminology used to express dilutions and adjust mathematical calculations accordingly
- Calculate solutions for stocks
- Interpret a dilution problems by setting up an appropriate as C1V1 = CFVF equation to solve for any one of the values
- Use multi term CV equations (C1V1 + C2V2 = CFVF) to solve problems in which multiple solutions containing a single molecular species are combined
- Inter convert expressions of concentrations: M, % mg/mL , ppm etc
- Interpret labeling of multi-component solutions that are expressed as fold concentrates (e.g., 10X PBS)
- Correctly interpret and apply the terms "fold" and volumes in relation to concentration solutions (e.g., dilute 10-fold, or add 9 volumes)

Unit 4 Data Presentation and Graphic Analysis

- Plot given points on a rectangular coordinate system.
- Graph linear relationships between two variables
- Establish and interpret appropriate scale
- Distinguish between and designate dependent and independent variables
- Determine the slope of a line an locate the x and y intercepts
- Transform linear data into the expression equation Y= mX+b (where m= slope and b = y intercept
- Determine whether a n equation describes a straight line
- Interpret limitation of linear equation applied to non-linear data (thresholds)
- Describe the benefits and limitations of least squares analysis as compared with estimating best fit of a line to a set of data points.
- Establish the mean of a given set of numbers
- Obtain standard deviation (sample and population) for a set of measurements with and without a calculator
- Calculate the coefficient of variation from the mean and standard deviation
- Construct and interpret error bars based on standard deviation
- Estimate and predict data from a graph
- Plot, graph and interpret exponential relationships using logs transformation and semi log paper
- Predict doubling times using graphic approach